September 2, 2025
10 Best Cat Flea And Tick Treatment of 2025
Last Updated - September 2, 2025
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Up to 11% off
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Frontline
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FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments
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Why We Love It
- FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
- Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
- FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
- Treat cats and dogs in the home monthly to effectively control fleas and ticks and prevent the establishment of new infestations
- Subscribe & save today to make it easier to keep your cat or dog protected year-round and make sure you never run out of FRONTLINE Plus
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PetArmor
PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs
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Main Highlights
- EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
- TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
- BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
- FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
- EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months
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Advantage
Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply
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Main Highlights
- Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
- Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
- Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
- Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
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CPFK
Chewable Flea Treatment for Cats Flea and Tick Prevention for Cats Chewables Fleas Chewables for Cat of All Breeds and Ages 300 Chewable Tablets
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Main Highlights
- Meow for all breeds and ages: Our cat flea and tick treatment chewable is effective for cats of all sizes, flea treatment for cats chewable delivers the desired results, cat chewable flea and tick meets the needs of kittens to senior cats, providing a full range of cat oral flea and tick prevention
- Safe ingredients: Our cat flea chewables is made from high quality ingredients, flea treatment for cats pill is free of GMOs, cellulose, canola, and is fortified with vitamins B1, B6, and B12, flea treatment for cats chewable provides cats with flea treatment for kittens, flea treatment for kittens strengthens your pet's immune system and skin health
- Easy to use: Forget the hassle of topical treatment for fleas in cats, flea and tick chewables for cats makes flea prevention for kittens a pleasure rather than a chore, just feed your cat a few tablets of chewable flea and tick for cats a day for effective flea and tick prevention for cats
- Best alternative: Just feed your dog a few tablets of cats flea and tick treatment pills a day and reliably flea and tick prevention for cats.cat flea treatment oral is a great alternative to collars, drops, sprays and shampoos, cat edible flea treatment keeps your cat safe from pests
- Cat flea and tick prevention: Effective with this cat flea and tick prevention from us, cat flea and tick treatment chewable ensures that your cat is provided with a full range of edible flea treatment for cats to continually ward off unwanted visitors
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Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)
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Main Highlights
- Same product, new lookThis product is identical in manufacturing and formulation as the Solimo brand
- One 6 dose pack of Amazon Basics Flea & Tick Treatment for Cats (over 1.5 lbs)
- Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
- Active ingredients (list ingredients) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
- One application provides up to 30 days of protection
- Waterproof: 24 hours after application your pets treatment is protected against rain and water activities
- Packaging received may vary: you may receive product in Solimo or Amazon Basics Packaging.
- Amazon Basics Flea and Tick Topical does not expire
- Satisfaction Guarantee: Were proud of our products. If you arent satisfied, well refund you for any reason within a year of purchase. 1-877-485-0385
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Amazon Basics
Amazon Basics Topical Flea Treatment for Large Cats (Over 9 Pounds), 4 Count (Previously Solimo)
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Main Highlights
- FAST-ACTING FLEA MEDICATION FOR CATS: Eliminates fleas in just 12 hours, providing your large cat with swift relief from discomfort with our effective flea medication for cats
- LONG-LASTING FLEA PREVENTION FOR CATS: Protect your cat from infestations for up to 4 weeks with each application of this flea remover, providing continuous and reliable flea prevention for cats
- TOPICAL CAT FLEA DROPS FOR REINFESTATION: This cat flea medicine proactively kills reinfesting fleas within 2 hours, efficiently halting the flea lifecycle
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
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Advantage
Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 1-Month Supply
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Main Highlights
- Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
- Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
- Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
- Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
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Our Rankings
PetArmor
PetArmor for Cats, Flea & Tick Treatment for Cats (Over 1.5 Pounds), Includes 3 Month Supply of Topical Flea Treatments
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Main Highlights
- CAT FLEA AND TICK CONTROL: SENTRY Fiproguard topical flea and tick prevention for cats kills fleas, ticks and chewing lice for up to 30 days.
- VET QUALITY FORMULA: SENTRY Fiproguard is a vet-quality formula flea treatment that contains the active ingredient fipronil.
- FOR KITTENS AND CATS: PetArmor topical flea treatment for cats and kittens 8 weeks and older for up to 30 days after application and helps prevents infestations of adult fleas.
- FLEA AND TICK PREVENTION: PetArmor for cats helps you protect your furry family member from the diseases fleas and ticks carry, including deer ticks that may transmit Lyme disease.
- INCLUDES: Three (3) 0.017 fl. oz. waterproof topical applications for cat flea and tick control. For best results, apply flea and tick treatment for cats directly to dry skin on your cats back, between the shoulder blades, on a monthly basis.
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Hartz
Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments
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Main Highlights
- Topical drop formula kills fleas and deer ticks
- Includes 3 monthly treatments in easy to apply, single dose tubes
- Repels mosquitoes for 18 days
- For use on cats and kittens 12 weeks and older weighing 5 pounds and over
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Seresto
Seresto Cat Vet-Recommended Flea & Tick Treatment & Prevention Collar for Cats | 8 Months Protection
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Main Highlights
- Vet-recommended, premium flea and tick protection for cats and kittens without the price tag
- Long-lasting flea and tick collar kills and repels fleas for 8 continuous months
- Seresto is veterinarian recommended flea and tick collar
- Starts working within 24 hours to kill and repel fleas and ticks by contact so pests dont have to bite your cat to die
- Hassle-free, non-greasy, easy-to-use flea and tick protection
